Table 1.
Aging perturbations of the early hematopoiesis Boolean model. This table summarizes the reachabilities of 5 HSPC states (preDiff and 4 fixed points pLymph, pNeuMast, pER, pMk) from states iHSC, srHSC or qHSC, in WT and 5 mutant simulations (a cross indicates that the HSPC-state is reachable). The last column reports the observations in our scRNA-seq data: Up (resp. down) arrows indicate an increase (resp. a decrease) upon aging in component activity or interaction score.
| pLymph | pNeuMast | pEr | pMk | preDiff | scRNAseq observations | |
|---|---|---|---|---|---|---|
| WT | X | X | X | X | X | |
| Junb KI | X | Junb ↑ in iHSC, qHSC, preDiff, pLymph, pMk | ||||
| Egr1 KI | X | X | Egr1 ↑ in iHSC, qHSC, preDiff, pMk | |||
| Fli1 KI | X | X | Fli1 ↑ in iHSC, preDiff, pMk | |||
| Spi1 KO | X | X | X | Spi1 ↓ in iHSC, preDiff, pLymph, pEr | ||
| Edgetic Gata2-Cebpa | X | X | Gata2 -> Cebpa ↓ Spi1 -> Cebpa ↑ |