Fig. 4. E(AH) treatment in human epidermal keratinocytes (HaCaT) inhibits the secretion of photoaginginduced matrix metalloproteinase-1 (MMP-1) and cytokines.

HaCaT cells were treated with a Ctl, EGCG, or various concentrations of E(AH) before or after irradiation with UVB (0.03 J/cm²). After 48 h, (A) MMP-1, (B) IL-6, and (C) IL-8 secretion levels in the supernatant were measured by ELISA assay. All data were indicated as mean ± SD of at least three independent experiments. Statistical analysis: *p < 0.05, **p < 0.01, ***p < 0.001 vs. Ctl-treated cells.