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. 2022 Dec 5;87:104386. doi: 10.1016/j.ebiom.2022.104386

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Th1 (A. IFN-γ release) and Th2 (B. IL-4 release) responses. The peripheral blood mononuclear cells (PBMC) were collected from the participants of phase 1 before vaccination, and on day 14 after booster vaccination (D14). The number of specific T cells with secretion of IFN-γ (Th1) and IL-4 (Th2) were measured with spot per 10⁶ PBMC using enzyme-linked immunospot (ELISpot) assay. Note: Only those with available baseline and post-boosting data were included; ∗∗p < 0.01, paired statistical comparison over time.