FIGURE 2.

The role of PEVs in PE. PEVs are increased in women affected with this condition, with multiple changes in their surface and cargo. These changes are different in early versus late-onset PE. A possible modulator of PEVs is the low oxygen tension and hypoxic environment. PEVs released by the placenta participates in the PE-associated vascular dysfunction, impairing placentation and trophoblast behavior, dysregulating the immune system and leading to different PE manifestations. This can arise potential translational opportunities for exploring.