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. 2022 Nov 21;12:1030590. doi: 10.3389/fonc.2022.1030590

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Copyright © 2022 Zhou, Xu, Tan, Zhou, Dong and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The identification of MMP1. (A) TC samples from the GEO database included in this study; (B) PCA map between PDTC/ATC and PTC. The difference between PTC and PDTC/ATC samples was not very large. (C) Volcano plots exhibited the DEGs between PDTC/ATC and PTC. (D) List of DEGs between PDTC/ATC and PTC. (E). Heat map of MMP1 and another top 40 DEGs between PDTC/ATC and PTC. (F) Single-cell sequencing data in five ATC and six PTC patients. (G) Four basic types of cells in single cell sequencing data: tumor/epithelial cells, immune cells, endothelial cells and fibroblasts. (H) MMP1 expression in different cells. (I) Relative quantification of MMP1 expression level. GEO, the Gene Expression Omnibus; PDTC, poorly differentiated thyroid cancer; ATC, anaplastic thyroid cancer; PTC, papillary thyroid cancer; DEG, differentially expressed gene.