TABLE 1.
List of miRNAs potentially involved in DIC.
| miRNA | After DOX treatment | Organism/cell | Targets | References |
|---|---|---|---|---|
| miR-34a | Upregulated | Rat cardiomyocytes | SIRT1, Bcl-2, TP53, MDM4, YY1, MTA2, HDAC1, c-Myc, n-Myc, CCND1, E2F, CDK4, CDK6, MET | Bommer et al. (2007), Yamakuchi et al. (2008), Kaller et al. (2011), Chen and Hu (2012), Navarro and Lieberman (2015), Piegari et al. (2016), Piegari et al. (2020) |
| miR-23a | Upregulated | Rat cardiomyocytes, primary neonatal rat ventricular myocytes | PGC-1α, (Complexes with p53 to increase miR-128 expression) | Li et al. (2015), Du et al. (2019) |
| miR-128 | Upregulated | Mouse cardiomyocytes | SIRT1, PPAR-γ | Ren et al. (2009), Zhang et al. (2021b) |
| miR-22 | Upregulated | Human colon cancer cells | p21 | Tsuchiya et al. (2011) |
| Mouse cardiomyocytes | SIRT1 | Xu et al. (2020), Wang R et al. (2021) | ||
| miR-146a | Upregulated | Mouse cardiomyocytes | ErbB4, TAF9b, cyclophilin D | Horie et al. (2010), Pan et al. (2019), Su et al. (2021) |
| miR-451 | Upregulated | Mouse cardiomyocytes | MO25 | Chen et al. (2012), Li et al. (2019a) |
| miR-25 | Upregulated | Mouse cardiomyocytes, H9c2 rat cardiomyoblasts | PTEN | Li et al. (2020d) |
| miR-143 | Upregulated | Mouse cardiomyocytes | AKT | Li et al. (2020c) |
| miR-375 | Upregulated | Mouse cardiomyocytes, H9c2 rat cardiomyoblasts, adult murine cardiomyocytes | PDK1 | Liu et al. (2020b) |
| miR-495-3p | Downregulated | Mouse cardiomyocytes | PTEN | Meng and Xu (2022) |
| miR-17-5p | Downregulated | Mouse cardiomyocytes | PTEN | Yu et al. (2020) |
| miR-21 | Upregulated | Mouse cardiomyocytes, H9c2 rat cardiomyoblasts | PTEN, BTG2 | Yang et al. (2014), Tong et al. (2015) |
| miR-208a | Upregulated | Mouse cardiomyocytes | GATA-4 | Tony et al. (2015) |
| Downregulated | Rat cardiomyocytes | Vacchi-Suzzi et al. (2012) | ||
| miR-199a-3p | Downregulated | Mouse cardiomyocytes, human-induced pluripotent cell-derived cardiomyocytes | GATA-4 | Xia et al. (2021) |
| miR-140-5p | Upregulated | Rat/mouse cardiomyocytes, H9c2 rat cardiomyoblasts | Nrf2, SIRT2 | Zhao et al. (2018) |
| miR-195 | Upregulated | AC16 human cardiomyocytes | Bcl-2, SIRT3 | Zhang et al. (2018), Chen et al. (2019a) |
| miR-330-5p | Upregulated | Human-induced pluripotent cell-derived cardiomyocytes | SIRT6, survivin, SERCA2a | Han et al. (2020) |
| miR-30 | Downregulated | Adult rat ventricular cardiomyocytes, H9c2 rat cardiomyoblasts, neonatal rat cardiac cells | β1AR, β2AR, (Downregulates p53) | Li et al. (2010), Roca-Alonso et al. (2015) |
| miR-30a | Downregulated | Rat cardiomyocytes | Beclin-1 | Lai et al. (2017), Zhang et al. (2021c) |
| miR-30e | Downregulated | Rat cardiomyocytes | Beclin-1 | Lai et al. (2017) |
| miR-499-5p | Downregulated | Mouse cardiomyocytes, H9c2 rat cardiomyoblasts | p21, α-/β-isoforms of calcineurin subunits | Wang et al. (2010), Wan et al. (2019) |
| miR-532-3p | Upregulated | Neonatal rat and mouse cardiomyocytes | ARC | Wang et al. (2015) |
| miR-140 | Upregulated | Neonatal rat cardiac cells | Mfn1 | Li et al. (2014a) |
| miR-147-y | — | Freshly isolated neonatal pig cardiomyocytes | Raptor | Gao et al. (2022) |
| miR-152-3p | Downregulated | H9c2 rat cardiomyoblasts, rat heart | ETS1 | Deng et al. (2022) |
| miR-6852 | — | A549 and H358 lung cancer cells | CBS | Wang et al. (2019) |
| miR-214 | — | Human and mouse brain | TfR1, PVT1, p53 | Lu et al. (2020) |
| miR-152 | Downregulated | Mouse cardiomyocytes | Keap1, TfR1 | Kindrat et al. (2016), Zhang et al. (2021a) |
| miR-7-5p | Inhibited | AC16 human cardiomyocytes, neonatal rat ventricle cardiomyocytes | TfR1 | Zhuang et al. (2021) |