Table 3.
Health economic assessment characteristics of the articles and reports.
| Articles and reports assessing antenatal screening (%) (n = 242) |
Articles and reports assessing newborn screening (%) (n = 95) |
|
|---|---|---|
| Study design | ||
| Individual patient-level data analysis | 12 (5.0) | 6 (6.4) |
| Cohort | 10 (4.1) | 5 (5.3) |
| Cross-sectional | 0 (0) | 1 (1.1) |
| Randomised controlled trial | 2 (0.8) | 0 (0) |
| Decision-analytical model | 200 (82.6) | 72 (76.6) |
| Decision tree | 90 (37.2) | 39 (41.5) |
| Decision tree and Markov model | 9 (3.7) | 6 (6.4) |
| Discrete event simulation model | 1 (0.4) | 1 (1.1) |
| Markov model | 10 (4.1) | 15 (16.0) |
| Model type not specified | 83 (34.3) | 8 (8.5) |
| Patient-level simulation model | 7 (2.9) | 3 (3.2) |
| Other | 2 (0.8) | 3 (3.2) |
| Not stated | 28 (11.6) | 13 (13.8) |
| Type of economic evaluationa | ||
| Cost-benefit analysis | 17 (7.0) | 5 (5.3) |
| Cost-consequences analysis | 7 (2.9) | 3 (3.2) |
| Cost-effectiveness analysis | 87 (36.0) | 47 (50.0) |
| Cost-minimisation analysis | 2 (0.8) | 3 (3.2) |
| Cost-utility analysis | 129 (53.3) | 38 (40.4) |
| Perspective of costsa | ||
| Health system or payer | 107 (43.5) | 53 (52.5) |
| Societal | 44 (17.9) | 25 (24.8) |
| Not applicableb | 0 (0) | 1 (1.0) |
| Not stated | 95 (38.6) | 22 (21.8) |
| Time horizon of decision-analytical model | ||
| Up to delivery | 9 (4.5) | 1 (1.4) |
| Up to 1 year | 26 (13.0) | 6 (8.3) |
| Between 1 year to specific time horizon excluding lifetime | 8 (4.0) | 14 (19.4) |
| Lifetime | 80 (40.0) | 37 (51.4) |
| Not stated | 77 (38.5) | 14 (19.4) |
| Sources to inform health benefits | ||
| Primary data collection | 21 (9.7) | 13 (14.1) |
| Evidence-synthesis of secondary data | 167 (77.3) | 62 (67.4) |
| Combination of primary and secondary data | 28 (13.0) | 16 (17.4) |
| Expert opinion only | 0 (0) | 1 (1.1) |
| Reporting of preference-based outcomes in cost-utility analysis | ||
| Maternal QALYs/DALYs | 94 (72.9) | 4 (10.5) |
| Infant QALYs/DALYs | 19 (14.7) | 34 (89.5) |
| Maternal and infant QALYs/DALYs | 16 (12.4) | 0 (0) |
a
Will not total up to 100% as some articles and reports reported more than one category.
b
This is a multiple-criteria decision analysis.