Table 2.
Correlations between performance in MWM trial and serum levels of inflammatory cytokines.
| Cognitive phase | Age | Group | IL-6 | IL-1β | TNF-α |
|---|---|---|---|---|---|
| r (p) | r (p) | r (p) | |||
| Learning distance swam | 3 months | CON | 0.687 (0.132) | 0.544 (0.265) | 0.794 (0.060) |
| CON-EE | 0.566 (0.242) | 0.799 (0.056) | 0.808 (0.052) | ||
| LPS | 0.862 (0.027)* | 0.846 (0.034)* | 0.818 (0.047)* | ||
| LPS-EE | 0.887 (0.019)* | 0.849 (0.032)* | 0.824 (0.044)* | ||
| 15 months | CON | 0.784 (0.065) | 0.793 (0.060) | 0.783 (0.065) | |
| CON-EE | 0.803 (0.054) | 0.687 (0.132) | 0.789 (0.062) | ||
| LPS | 0.876 (0.022)* | 0.868 (0.025)* | 0.826 (0.043)* | ||
| LPS-EE | 0.891 (0.017)* | 0.8198 (0.046)* | 0.849 (0.032)* | ||
| Percentage of distance swam in the target quadrant | 3 months | CON | −0.793 (0.060) | −0.508 (0.303) | −0.752 (0.085) |
| CON-EE | −0.714 (0.111) | −0.698 (0.123) | −0.752 (0.085) | ||
| LPS | −0.616 (0.193) | −0.752 (0.085) | −0.764 (0.077) | ||
| LPS-EE | −0.775 (0.070) | −0.664 (0.150) | −0.655 (0.158) | ||
| 15 months | CON | −0.810 (0.051) | −0.657 (0.156) | −0.775 (0.071) | |
| CON-EE | −0.694 (0.126) | −0.754 (0.084) | −0.758 (0.081) | ||
| LPS | −0.831 (0.040)* | −0.852 (0.031)* | −0.864 (0.026)* | ||
| LPS-EE | −0.879 (0.021)* | −0.824 (0.044)* | −0.6969 (0.124) | ||
| Percentage of time spent swimming in the target quadrant | 3 months | CON | −0.750 (0.086) | −0.348 (0.499) | −0.675 (0.141) |
| CON-EE | −0.274 (0.600) | −0.629 (0.181) | −0.463 (0.355) | ||
| LPS | −0.832 (0.040)* | −0.821 (0.045)* | −0.860 (0.028)* | ||
| LPS-EE | −0.725 (0.103) | −0.603 (0.205) | −0.645 (0.167) | ||
| 15 months | CON | −0.664 (0.151) | −0.254 (0.628) | −0.808 (0.052) | |
| CON-EE | −0.331 (0.520) | −0.608 (0.200) | −0.472 (0.345) | ||
| LPS | −0.838 (0.037)* | −0.867 (0.026)* | −0.846 (0.034)* | ||
| LPS-EE | −0.810 (0.051) | −0.810 (0.051) | −0.634 (0.176) |
*Denotes significant correlation coefficients (*p < 0.05); Significant p-values are marked in bold. CON, untreated control group; LPS, lipopolysaccharide treatment group; EE, group of mice exposed to environmental enrichment.