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. 2022 Nov 21;13:1030610. doi: 10.3389/fimmu.2022.1030610

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Copyright © 2022 Li, Ye, Peng, Zeng, Chen and Zeng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of transcriptional activation of inflammatory cytokines by histone methyltransferases and demethylases. Histone methylation occurs at the N-terminus of Lysine or Arginine residues of Histone H3 and H4, including H3K4, H3K9, H3K27, H3K36, and H4K20. SMYD2, EZH2, G9a, SETD4, SET7/9, ASH1L and SMYD5 are histone methyltransferases. KDM6B (JMJD3), KDM6A, LSD1 and DHF2 are histone demethylases. ISG, IFN-stimulated gene; TNFaip3, a negative regulator of TLR signaling pathway.