Table 1.

Antimicrobial activity of his tones and his tone fragments.

Histone		Origin	Antimicrobial Spectrum					References
			Gram-positive	Gram-negative	Virus	Fungi	Parasites
H1	Full-length	murine	L.Monocytogenes, S.aureus, M.fortuitum	E.Coli, S.typhimurium	Unknown	C. neoformans	Unknown	(34)
		human	E. faecalis, S.aureus, S. Epidermidis, MRSA	P. aeruginosa, E. coli, S. typhimurium	HPV,HIV-1, Norwalkvirus	C. tropicalis	Unknown	(7, 35–42)
		fish	S. aureus	E. coli	Unknown	Unknown	Unknown	(43)
		chicken	B. subtilis	E. coli	Unknown	Unknown	Unknown	(44)
		wheat	Unknown	Unknown	Unknown	Aspergillus, Fusarium, Penicillium,Greeneria	Unknown	(45)
	N-terminal	fish	B.subtilis, L.ivanovii	V. alginolyticus, E. coli A. hydrophila,S. enterica	Unknown	Unknown	Unknown	(46)
	Onchorhyncin II	fish	L.anguillarum, M.luteus,P.citreus	E. coli	Unknown	Unknown	Unknown	(47)
H2A	Full-length	human	Unknown	E. coli	HIV-1, Norwalkvirus, Influenzavirus	Unknown	L. amazonensis, L. amazonensis, L.mexicana,L.major	(40–42, 48, 49)
		calf	S.aureus	S. flexneri, S.typhimurium	Unknown	Unknown	Unknown	(50)
		chicken	B. subtilis	E. coli	Unknown	Unknown	Unknown	(51)
		fish	A. Viridans, M. luteus R. salmoninarum P. citreus,S. aureus B. subtillis	A. hydrophila, A.salmonicida, L. anguillarum, E.coli,Y.ruckeri	Unknown	Unknown	Unknown	(52)
		shrimp	M. luteus	Unknown	Unknown	Unknown	Unknown	(53)
	Buforin I and Buforin II	frog	B. subtilis, S. aureus,S. mutans	S. typhimurium, E.coli, P. putida	Unknown	C. neoformans, S. cerevisae, C. albicans	Unknown	(54, 55)
	Parasin I	catfish	B. subtilis, S. aureus, S. mutans	S. Enteritidis E. coli, P. putida	Unknown	C. neoformans, S. cerevisae, C. albicans	Unknown	(56)
	Hipposin	fish	B. subtilis	E. coli	Unknown	Unknown	Unknown	(57, 58)
H2B	Full-length	human	Unknown	E. coli	HPV, Norwalkvirus, Influenzavirus	Unknown	L. braziliensis, L. amazonensis, L. mexicana, L. major	(39, 41–43, 49)
		murine	L. Monoctogenes, S. aureus,M. forutitum	E. coli, S.typhimurium	Unknown	C. neoformans	Unknown	(34)
		chicken	B. subtilis	E. coli	Unknown	Unknown	Unknown	(51)
		fish	B. megaterium	E. coli	Unknown	C. albicans	Unknown	(59)
	C-terminal	chicken	B. subtilis	E. coli	Unknown	Unknown	Unknown	(51)
	N-terminal	human	M.luteus, B.megaterium	Unknown	Unknown	Unknown	Unknown	(60)
H3	Full-length	human	S. aureu	E. coli	Norwalkvirus, Influenzavirus	Unknown	Unknown	(41, 42, 61)
H4	Full-length	human	S. aureus, P. acnes	Unknown	Norwalk virus, Influenza virus	Unknown	Unknown	(41, 42, 62)
		calf	S.aureus	E.coli	Unknown	Unknown	Unknown	(61)
		wheat	Unknown	Unknown	Unknown	Aspergillus, Fusarium, Penicillium,Greeneria,	Unknown	(45)
	Histogrannin	calf	B. subtilis, S. aureus	E. coli, P. aeruginosa	Unknown	Unknown	Unknown	(63)