Table 3.
Psychiatric disorders (columns 2 and 3) and comorbidities (column 4) in the four generations of an informative family (column 1) whose mother (first generation) took DES for 3 months after each delivery (see Figure 2 ).
| Patient | Psychiatric disorder | Diagnosis | Associated non-psychiatric disorders | Suicide attempt(s) | Death by suicide |
|---|---|---|---|---|---|
| II-1 ♀ | no | no | no | no | no |
| II-2 ♂ | no | no | Uvula bifida, death due to ruptured congenital brain aneurysm at 26 years of age | no | no |
| II-3 ♂ | yes | Bipolar disorder, chronic alcoholism | Deafness of left ear | yes | yes (at 42 years of age) |
| II-4 (♀ twin) | yes | Eating disorder | Endometriosis | no | no |
| II-5 (♂ twin) | yes | Bipolar disorder, chronic alcoholism | Chronic cirrhosis death at 51 years of age | yes | no |
| II-6 ♀ | yes | Bipolar disorder |
Endometriosis, inverted kidney/bladder | yes | no |
| II-7 ♀ | yes | Bipolar disorder, chronic alcoholism, eating disorder | Endometriosis, sacrococcygial teratoma, rectal adenocarcinoma, breast cancer | yes | no |
| II-8 ♀ | yes | Bipolar disorder, chronic alcoholism | Endometriosis, fibromyalgia, obesity | yes | no |
| II-9 ♀ | yes | Bipolar disorder, chronic alcoholism | Endometriosis | yes | no |
| II-10 ♀ | yes | Bipolar disorder, chronic alcoholism | Endometriosis | yes | yes (at 50 years of age) |
| II-I1 ♂ | yes | Bipolar disorder, chronic alcoholism | no | yes | no |
| III-1 ♀ | no | no | no | no | no |
| III-2 ♂ | no | no | no | no | no |
| III-3 ♂ | no | no | no | no | no |
| III-4 ♀ | no | no | no | no | no |
| III-5 ♀ | no | no | no | no | no |
| III-6 ♀ | no | no | no | no | no |
| III-7 ♂ | no | no | no | no | no |
| III-8 ♀ | no | no | no | no | no |
| III-9 ♂ | no | no | no | no | no |
| III-10 ♀ | no | no | Endometriosis | no | no |
| III-11 ♂ | no | no | Hypospadias | no | no |
| III-12 ♂ | / | Very premature baby, anencephaly, deceased | / | / | / |
| III-13 ♂ | X | ASD, Asperger syndrome | Hypospadias | no | no |
| III-14 ♂ | X | ASD, Asperger syndrome | no | no | no |
| III-15 ♂ | X | ASD, learning disorder (dyspraxia) | no | no | no |
| III-16 ♀ | X | Mood and sleep disorders | Endometriosis | no | no |
| III-17 ♂ | / | Very premature baby, (deceased at day 3 post-partum) | / | / | / |
| III-18 ♀ | X | Bipolar disorder, eating disorders | Endometriosis | no | no |
| III-19 ♀ | X | Bipolar disorder, eating disorders | Endometriosis | no | no |
| III-20 ♀ | no | no | Endometriosis | no | no |
| III-21 ♂ | X | Behavioral disorders | no | no | no |
| III-22 ♂ | X | Learning disorder (dyspraxia) | no | no | no |
| III-23 ♂ | no | no | no | no | no |
| III-24 ♀ | X | Bipolar disorder, learning disorder | Endometriosis | no | no |
| III-25 ♀ | X | Bipolar disorder, learning disorder | Endometriosis | no | no |
| III-26 ♂ | no | no | no | no | no |
| III-27♀ | no | no | no | no | no |
| IV-1 ♀ | no | no | no | no | no |
| IV-2 ♂ | / | / | / | / | / |
| IV-3 ♀ | no | no | no | no | no |
| IV-4 ♂ | / | no | no | no | no |
| IV-5 ♀ | no | no | no | no | no |
| IV-6 ♀ | no | no | no | no | no |
| IV-7 ♂ | yes | ASD, learning disorder (dyspraxia) | no | no | no |
| IV-8 ♂ | / | / | / | / | / |
| IV-9 ♀ | / | / | / | / | / |
| IV-10 ♂ | / | / | / | / | / |
| IV-11 ♂ | / | / | / | / | / |