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. 2022 Nov 21;13:1022850. doi: 10.3389/fimmu.2022.1022850

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Copyright © 2022 Deng, Zhao, Lv, Ma, Zhang, Xu, Zhou, Chen and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Visualization and module identification using two different PPI networks. (A) RRA-DEGs were mapped using Cytoscape software (genes mainly expressed in CD are indicated in blue, and genes mainly expressed in UC are indicated in orange). Using the MCODE plug-in, the module with the highest scores was identified (indicated in yellow). (B) The identified module comprised MMP1, MMP12, PLAU, MMP9, CXCL1, MMP10, PTGS2, TIMP1, and MMP7 (indicated in orange), with MMP3 as the seed gene (indicated in yellow). Functional enrichment analyses of the genes in the MMP-associated module were performed (C). (D) The intersection-DEGs were mapped using Cytoscape software (genes mainly expressed in CD are indicated in blue, and genes mainly expressed in UC are indicated in orange). Using the MCODE plug-in, the module with the highest scores was identified (indicated in yellow). (E) The identified module comprised MMP12, MMP10, MMP3, MMP9, TIMP1, CXCL1, PLAU, S100A9, CXCL13, S100A8, ANXA1 and S100A12 (indicated in orange), with MMP7 as the seed gene (indicated in yellow). Functional enrichment analyses of the genes in the MMP-associated module were performed (F).