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. 2022 Nov 9;298(12):102686. doi: 10.1016/j.jbc.2022.102686

Figure 5.

Figure 5

Effects of OSM on the mRNA expression of exercise-induced chemokines in the skeletal muscle.A, expression of chemokines in the skeletal muscle after the aerobic exercise. Male C57BL/6J mice were subjected to a single bout of treadmill running exercise at a speed of 15 m/min for 1 h. Mice in the sedentary group were used as controls. B, the expression of chemokines in the skeletal muscle of WT and OSM−/− mice at 1 h after the exercise. Male WT and OSM−/− mice were subjected to a single bout of treadmill running exercise at a speed of 15 m/min for 1 h. C, effects of OSM on the expression of chemokines in the skeletal muscle of mice at 1 or 2 h after the intramuscular injection of vehicle or recombinant mouse OSM (12.5 ng/g body weight). Data are expressed as mean ± SD; n = 5 per group. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001. Two-way ANOVA followed by Tukey’s post hoc test. CCL, CC chemokine ligand; CXCL1, CXC chemokine ligand 1; OSM, oncostatin M.