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. 2022 Nov 9;8(1):101122. doi: 10.1016/j.adro.2022.101122

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Metabolomic analysis of metabolites altered upon CPI-613–radiation therapy (RT) combination treatment. MiaPaCa-2 cells were exposed to either CPI-613, 2 Gy RT, or their combination for 6 or 24 hours. Targeted metabolomics was then performed as described in Methods and Materials. Statistically significant and differentially expressed metabolites are presented (P < .05). (A, B) Venn diagram showing increased number of altered metabolites in the combination. (C, D) Heat maps showing top prioritized targets in 6 and 24 hours of treatment, respectively.