TABLE 1.

Protective efficacies of vaccines emulsified in DDA

Vaccine groupc	Expt 1a			Expt 2b
	Log10 CFUd	Log10 resistancee	Pf	Log10 CFU	Log10 resistance	P
Naive	5.06 ± 0.04			5.74 ± 0.12
DDA	5.04 ± 0.05	<0.05		5.75 ± 0.08	<0.05
BCG	4.33 ± 0.06	0.73	0.008	4.76 ± 0.18	0.98	0.008
ST-CF–DDA	3.94 ± 0.08	1.10	0.008	4.94 ± 0.11	0.81	0.006
Ag85B–DDA	4.29 ± 0.05	0.75	0.007	NDg	ND
ESAT-6–DDA	4.93 ± 0.01	0.11		5.50 ± 0.02	0.25	0.009

^aMice received an i.v. challenge, and bacterial loads in the liver were determined. 

^bMice received an aerosol TB infection, and bacterial loads in the lungs were determined. 

^cMice were vaccinated once with BCG or three times at 2-week intervals with the subunit vaccines. 

^dGeometric means ± standard error of the means. Data are means based on duplicate analysis of five animals in each group. 

^eProtective efficacies of vaccines, expressed as log₁₀ reductions in bacterial loads compared to those in the adjuvant controls. 

^fP values are given for bacterial loads significantly different from those in control mice. 

^gND, not done.