表 6.
152例免疫联合治疗NSCLC患者PFS单因素与多因素Cox回归分析
Univariate and multivariate Cox regression analysis of PFS in 152 NSCLC patients treated with combined immunotherapy
| Characteristics | Univariate analysis | Multivariate analysis | |||
| HR (95%CI) | P | HR (95%CI) | P | ||
| Age (< 65 yr vs ≥65 yr) | 1.01 (0.706-1.446) | 0.955 | |||
| Gender (Female vs Male) | 1.423 (0.916-2.21) | 0.116 | |||
| ECOG PS (0-1 vs 2) | 1.827 (1.172-2.848) | 0.008 | 1.241 (0.769-2.002) | 0.376 | |
| Smoking (Yes vs No) | 1.177 (0.835-1.661) | 0.352 | |||
| Histology (Squamous vs Non-squamous) | 1.057 (0.749-1.493) | 0.751 | |||
| TNM stage (III vs IV) | 1.256 (0.998-1.579) | 0.052 | |||
| Lines of treatment (1 vs ≥2) | 1.173 (0.816-1.684) | 0.389 | |||
| DNLR (< 0 vs ≥0) | 1.149 (0.81-1.63) | 0.437 | |||
| NLR (< 5 vs ≥5) | 2.405 (1.636-3.537) | < 0.001 | 1.408 (0.886-2.238) | 0.148 | |
| dNLR (≤3 vs > 3) | 2.061 (1.448-2.934) | < 0.001 | 1.779 (1.187-2.666) | 0.005 | |
| LDH (≤245 IU/L vs > 245 IU/L) | 2.179 (1.519-3.124) | < 0.001 | 1.926 (1.304-2.845) | < 0.001 | |