表 2.

人肺腺癌细胞株PC9、PC9/BB4、A549细胞株联合不同浓度STE029处理后对吉非替尼IC₅₀的影响

Comparison of Gefitinib IC₅₀ in PC9, PC9/BB4, A549 cell lines after in combination with STE029

Cell line	STE029 concentration	Gefitinib IC50 (μmol/L) (Mean, 95%CI)	P a
a: comparison of Gefitinib IC50 under different concentration of STE029 in PC9, PC9/BB4 and A549 cell lines, respectively.
PC9	0 μmol/L	0.128 (0.075-0.218)	-
	0.5 μmol/L	0.006 (0.003-0.009)	0.007,4
	1 μmol/L	0.004 (0.002-0.008)	0.013,3
	2 μmol/L	0.003 (0.002-0.006)	0.011
PC9/BB4	0 μmol/L	11.410 (10.670-12.200)	-
	4 μmol/L	2.606 (1.988-3.417)	0.021
	6 μmol/L	1.910 (1.402-2.603)	0.031
	8 μmol/L	0.924 (0.580-1.472)	0.034
A549	0 μmol/L	14.390 (13.320-15.550)	-
	4 μmol/L	10.760 (8.344-13.870)	0.135
	6 μmol/L	10.660 (8.337-13.640)	0.098
	8 μmol/L	6.251 (4.934-7.919)	0.004