TABLE 2.
Effect of immunization with pneumococcal proteins on nasal carriage of L82016
| Immunogen(s) | No. of mice | CFU/nasal wash (mean log [standard error]) |
P value of immunogen(s) versus CTB only
|
|
|---|---|---|---|---|
| Student's t test | Wilcoxon test | |||
| CTB only | 11 | 4.48 (0.21) | ||
| PspA | 10 | 3.36 (0.34) | 0.01 | 0.013 |
| PsaA | 10 | 2.14 (0.25) | <0.0001 | <0.0001 |
| PdB | 4 | 5.22 (0.09) | 0.64 | 0.078 |
| PspA + PsaA | 10 | 1.70 (0.08)a | <0.001 | <0.0001 |
| PspA + PdB | 4 | 5.10 (0.22) | 0.14 | 0.18 |
a
Seven of the 10 mice in this group had undetectable levels of CFUs (<60 CFU per nasal wash).