Table 6. Energies of o-nitro­sul­fonamides 1–3 and N-cyclo­amino-o-sul­fan­il­amides 4–6 with the hCA II (PDB entry 4iwz) and hCA IX (5fl4) isoenzymes.

Entry	Docking score		E-model		Ligand efficiency
	4iwz	5fl4	4iwz	5fl4	4iwz	5fl4
1	−1.351	−0.807	−38.102	−40.980	−0.079	−0.047
2	−2.223	−1.977	−41.329	−42.073	−0.124	−0.110
3	−1.288	−1.538	−40.486	−38.954	−0.061	−0.073
4	−1.645	−1.451	−37.113	−35.898	−0.110	−0.097
5	−1.636	−1.605	−41.034	−34.609	−0.102	−0.100
6	−0.784	−1.368	−47.945	−42.454	−0.041	0.072
A	−2.252	–	−55.202	–	−0.125	–
B	–	−1.969	–	−41.029	–	−0.082

Note: A is N-(5-sulfamoyl-1,3,4-thia­di­azol-2-yl)-2-(thio­phen-2-yl)acetamide and B is 5-[1-(naph­tha­len-1-yl)-1,2,3-tri­azol-4-yl]thio­phene-2-sul­fonamide.