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. Author manuscript; available in PMC: 2022 Dec 5.
Published in final edited form as: N Engl J Med. 2014 Jul 3;371(1):58–66. doi: 10.1056/NEJMra1214243

Table 1.

Classifications of Acute Kidney Injury and Chronic Kidney Disease.*

Stage Assessments
Acute kidney injury Serum Creatinine Concentration Urine Output
1 1.5–1.9× baseline or ≥0.3 mg/dl above baseline <0.5 ml/kg/hr for 6–12 hr
2 2.0–2.9× baseline <0.5 ml/kg/hr for >12 hr
3 ≥3.0× baseline, ≥4.0 mg/dl, or initiation of renal-replacement therapy <0.3 ml/kg/hr for ≥24 hr or anuria for ≥12 hr
Chronic kidney disease Definition GFR
ml/min/1.73 m 2
1 Kidney damage with normal GFR ≥90
2 Kidney damage with mild decrease in GFR 60–89
3A Mild-to-moderate decrease in GFR 45–59
3B Moderate-to-severe decrease in GFR 30–44
4 Severe decrease in GFR 15–29
5 End-stage renal disease <15
*

The stage of acute kidney injury is determined according to the Kidney Disease Improving Global Outcomes Acute Kidney Injury Classification,6 and that of chronic kidney disease according to the glomerular filtration rate (GFR).2 Kidney damage is usually detected by means of an increased urinary albumin-to-creatinine ratio. To convert the values for creatinine to micromoles per liter, multiply by 88.4.