Table 2.
Association between TDLU measures and breast cancer subtype among 247 adjacent normal breast tissue slides
| TDLU measure | Unadjusted | Adjusted* | Adjusted** | ||
|---|---|---|---|---|---|
| Luminal A (n = 174) | TNBC (n = 73) | TNBC versus Lum. A | TNBC versus Lum. A | TNBC versus Lum. A | |
| n (%) | n (%) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| TDLUs present | |||||
| Yes | 161 (93%) | 72 (99%) | Ref | Ref | Ref |
| No | 13 (7%) | 1 (1%) | 0.17 (0.02, 1.34) | 0.20 (0.03, 1.54) | 0.16 (0.02, 1.20) |
| TDLU count/100 mm2 | |||||
| Tertile 1 | 58 (33%) | 13 (18%) | Ref | Ref | Ref |
| Tertile 2 | 57 (33%) | 23 (32%) | 1.80 (0.84, 3.86) | 1.81 (0.85, 3.85) | 1.60 (0.73, 3.51) |
| Tertile 3 | 59 (34%) | 37 (51%) | 2.80 (1.32, 5.92) | 2.44 (1.14, 5.22) | 2.18 (0.99, 4.79) |
| P-trend 0.01 | P-trend 0.02 | P-trend 0.06 | |||
| Median TDLU span (µm)*** | |||||
| Tertile 1 | 53 (33%) | 9 (13%) | Ref | Ref | Ref |
| Tertile 2 | 54 (34%) | 30 (42%) | 3.27 (1.41, 7.57) | 3.11 (1.34, 7.19) | 3.17 (1.32, 7.61) |
| Tertile 3 | 54 (34%) | 33 (46%) | 3.60 (1.51, 8.60) | 2.98 (1.21, 7.36) | 2.77 (1.07, 7.16) |
| P-trend 0.01 | P-trend 0.02 | P-trend 0.05 | |||
| Median acini count/TDLU*** | |||||
| Tertile1 | 64 (40%) | 18 (25%) | Ref | Ref | Ref |
| Tertile2 | 49 (30%) | 24 (33%) | 1.74 (0.83, 3.66) | 1.61 (0.77, 3.36) | 1.46 (0.70, 3.07) |
| Tertile3 | 48 (30%) | 30 (42%) | 2.22 (1.06, 4.68) | 1.93 (0.88, 4.22) | 1.77 (0.79, 3.98) |
| P-trend 0.03 | P-trend 0.10 | P-trend 0.17 |
Cut points based on distribution in Luminal A cases. TDLU count tertile cutpoints: T1 ≤ 4.81, T2 > 4.81 and ≤ 15.84, T3 > 15.84; Median TDLU span: T1 ≤ 394.7, T2 > 394.7 and ≤ 600.0, T3 > 600.0; Median acini count/TDLU: T1 ≤ 6, T2 > 6 and ≤ 15.5, T3 > 15.5
*Logistic regression models adjusted for categorical age and BMI fitted with a trend coding
**Adjusted for categorical age, BMI, and tumor size fitted with a trend coding
***Among women with TDLUs
P-values < 0.05 are noted in bold