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. 2022 Dec 5;17:92. doi: 10.1186/s13000-022-01273-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Representative figures for three p53 immunohistochemistry patterns. A Invasive ductal carcinoma of the breast harboring TP53 H193R mutation (Hematoxylin & Eosin, × 1.25 objective lens). B Diffuse strong immunoreactivity for p53, that is overexpression pattern (p53 immunohistochemistry, × 1.25 objective lens). C Low grade papillary serous carcinoma of the ovary without any oncogenic TP53 mutation (Hematoxylin & Eosin, × 10 objective lens) D Approximately a half of the tumor cells express p53 in the nuclei, that is usual pattern (p53 immunohistochemistry, × 10 objective lens). E Adenocarcinoma of the colon harboring TP53 H214Qfs*2 mutation (Hematoxylin & Eosin, × 4 objective lens). F Tumor cells are completely negative for p53 protein expression. Adjacent non-neoplastic cells showing p53 expression serves as an internal positive control. This pattern is classified as null pattern (p53 immunohistochemistry, × 4 objective lens)