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. 2022 Dec 5;41:333. doi: 10.1186/s13046-022-02546-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Progranulin modulates focal adhesion turnover and the formation of F-actin-containing cell protrusions. A-B Serum-starved parental and GRN KO MSTO-211H cells were treated with 10 µM nocodazole (NCZ) for 4 h. Nocodazole was then washed out to allow microtubules regrowth and focal adhesion assembly. Cells were fixed at the indicated time points after nocodazole release and stained for pFAK Y397 and vinculin (A) or vinculin and F-actin (B) by immunofluorescence. Bars = 20 µm. Arrows indicate focal adhesion (A) or F-actin containing cell protrusions (B)