Table 2.
Characteristics of participants in dataset 2
| Characteristic | Total sample (n = 114) | Controls (n = 56) | AD (n =58) | P value |
|---|---|---|---|---|
| Age, mean (SD) | 68.7 (6.5) | 68.3 (6.6) | 69.1 (6.4) | 0.50 |
| Education year, mean (SD) | 8.9 (2.2) | 9.1 (2.3) | 8.7 (2.1) | 0.94 |
| Women, no. (%) | 59 (51.8) | 29 (51.8) | 30 (51.7) | 1.00 |
| APOE ε4 positive (%) | 34 (29.8) | 10 (17.9) | 24 (41.4) * | < 0.001 |
| MMSE score (SD) | 24 (5.2) | 28.9 (0.7) | 19.2 (2.4) * | < 0.001 |
| Aβ42 (pg/ml), mean (SD) | 526.6 (215.8) | 702.3 (149.5) | 357 (105.8) * | < 0.001 |
| P-tau181 (pg/ml), mean (SD) | 83.3 (56.1) | 46 (24.8) | 119.2 (54.4) * | < 0.001 |
| P-tau181/Aβ42, mean (SD) | 0.20 (0.16) | 0.07 (0.03) | 0.33 (0.11) * | < 0.001 |
| T-tau (pg/ml), mean (SD) | 496.5 (202.3) | 317.2 (84.9) | 616.6 (171.4) * | < 0.001 |
The values of age, education years, and MMSE are shown as mean (standard deviation)
Abbreviations: AD, Alzheimer’s disease; Aβ, amyloid β; APOE ε4, apolipoprotein ε4; MMSE, Mini-Mental State Examination; P-tau, phosphorylated tau; SD, standard deviation; T-tau, total tau
*P < 0.05 compared to controls