TABLE 4.
Statistical significance of the delayed killing of mice by TX5179 and TX5180 compared with OG1RF
| Strain | No. of CFU/mla
|
Pb | No. of CFU/mla
|
Pb | ||
|---|---|---|---|---|---|---|
| OG1RF | TX5179 | OG1RF | TX5180 | |||
| 1 | 2.3 × 108 (6) | 3.3 × 108 (6) | 0.0034 | 2.3 × 108 (6) | 3.2 × 108 (6) | 0.0178 |
| 2 | 2.3 × 108 (6) | 6.6 × 108 (6) | 0.0009 | |||
| 3 | 3.5 × 108 (6) | 4.0 × 108 (16) | <0.0001 | 3.5 × 108 (6) | 5.0 × 108 (16) | 0.0002 |
a
Size of the inoculum used for injection into the peritoneum of each mouse. Numbers in parentheses are the number of mice used for each inoculation. The time-to-death values for wild-type and mutants are shown in Fig. 4.
b
The P value was calculated in the StatView program using the log rank method. A P value of less than 0.05 is statistically significant.
c
The LD50 values calculated for the three strains in this experiment were as follows (in CFU per milliliter): for OG1RF, 2.4 × 108; for TX5179, 6.0 × 108; and for TX5180, 5.0 × 108.