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. 2022 Dec 5;12:195. doi: 10.1186/s13578-022-00934-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — AURKA acts as an oncoprotein in PTC. A The protein level of AURKA was detected in AURKA knockdown TPC-1 cells and AURKA-overexpressing KTC cells by western blotting. B The viability of shAURKA-transfected TPC-1 cells or AURKA-overexpressing plasmid-transfected KTC cells compared with control cells was detected using the CCK-8 assay. C The shAURKA-transfected TPC-1 cells and AURKA-overexpression plasmid-transfected KTC cells were cultured for 10 days prior to crystal violet staining. D The ratio of EdU-labelled cells to total cells was observed in AURKA knockdown TPC-1 cells and AURKA-overexpressing KTC cells compared with the control group (original magnification × 20). E Transwell migration assays were used to detect the migration ability of AURKA knockdown TPC-1 cells and AURKA-overexpressing KTC cells compared with control cells. F Representative images of subcutaneous xenografts in nude mice derived from PLKO-transfected TPC-1 cells and shAURKA-transfected TPC-1 cells. n = 5 mice per group. Data are shown as the mean ± SD of three replicates (*P < 0.05, **P < 0.01, ***P < 0.001)