Table 1.
Comparison of main characteristics of previously published TYRII case reports, with emphasis on ocular lesions at initial clinical presentation (presented in author alphabetical order).
| References | Sex | Age at onset of symptoms | Age at presentation | Symptoms and/or clinical findings at presentation | Initial diagnosis and treatment | Clinical evolution following initial treatment |
|---|---|---|---|---|---|---|
| Charlton [10] | Case 1: M Case 2: F |
Case 1: 6 w Case 2: 6½ mo |
Case 1: 3 mo Case 2: 11 mo |
Case 1: Bilateral photophobia and conjunctival injection, with central corneal dendritic-like lesions. Case 2: Conjunctival injection and photophobia in her left eye. Dendritic lesions without conjunctival injection in her right eye |
Case 1: Initial diagnosis not defined, treated with topical antibiotics for 6 weeks, then refered for HSV keratitis. Case 2: Bilateral recalcitrant HSV keratitis, treated with topical antibiotics, cycloplegics, topical glucocorticoids, arabinoside, trifluorothymidine, and debridement |
Case 1: No improvement. Case 2: Sporadic improvement and exacerbations apparently not related to treatment |
| Colditz [12] | Case 1: M Case 2: F Case 3 and 4: N/A (palmo-plantar lesions at presentation) |
Case 1: 3 mo Case 2: 5 w |
Case 1: 4 yo Case 2: 2 yo |
Case 1: Unilateral epiphora, photophobia, and blepharospasm. Dendritic corneal ulcers at 5 mo. Case 2: Conjonctival injection and photophobia. Central corneal dendritic ulcers at 5 mo |
Case 1: HSV, treated with topical idoxuridine for 2 months. Case 2: N/A |
Case 1: Increased photophobia. Case 2: N/A |
| Goddé-Jolly [13] | F | 10 days | 7 mo | Conjonctivitis of the left eye, with mild corneal haze | Purulent conjonctivitis, treated with antibiotics eyedrops for 3 weeks | Increased corneal haze and extension of conjunctivitis symptoms to the right eye |
| Gokhale [14] | N/A | 2 mo | 5 mo | Photophobia, corneal haze, followed by bilateral dendritic keratitis | Conjunctivitis, treated with antibiotics eyedrops for 2 months, followed by suspicion of HSV keratitis, treated by acyclovir ointment for 2 weeks | No improvement |
| Hervé [15] | Case 1: F Case 2: F |
Case 1: First days of life. Case 2: First days of life. |
Case 1: 16 yo Case 2: 8 mo |
Case 1: Conjunctivitis, photophobia, epiphora. Case 2: Conjunctivitis, photophobia, pain |
Case 1: Chronic conjunctivitis and HSV keratitis, treated with antibiotics, allergy medications, homeopathy. Case 2: HSV keratitis, treated with eyedrops medication (N/S) |
Case 1: No improvement. Case 2: No improvement, dendritic keratitis noticed at 1 yo |
| Kymionis [18] | M, twins | 9 mo | 15 mo | Eye rubbing, photophobia, and epiphora | Bilateral HSV keratitis, treated with Topical trifluridine for 2 months prior to presentation | No improvement |
| Macsai [8] | Report of 9 cases. Details given for Case 1 (F) and Case 9 (M) |
Birth to 11 mo Case 1: 1 mo Case 9: 11 mo |
3 mo to 57 yo Case 1: 5 mo 1/2 Case 9: 11 mo |
Photophobia, redness, tearing, blepharospasm, pain, eye rubbing. Case 1: Photophobia Case 9: Eye rubbing, photophobia |
7/9 (78%) diagnosed and treated for HSV keratitis with topical trifluridine. Case 1: HSV keratitis, treated with eyedrops trifluridine. Case 9: Diagnosis N/S, treated with eyedrops trifluridine |
4/7 (57%) showed transient resolution. Case 1: Resolution of symptoms, clinical signs still present (superficial right corneal haze, and dendritiform pattern in left cornea). Case 9: Less symptomatic, large dendritiform epithelial lesion on right cornea |
| Podglajen-Wecxsteen [16] | M | 9 mo | 20 yo | Tearing, conjunctival injection | Allergic conjunctivitis, treated accordingly (N/S) | No improvement |
| Tsai [17] | F | Birth | 2 yo | Photophobia, epiphora | HSV keratitis, treated accordingly (N/S) | No improvement |
| Soares [11] | M | 2 mo | 2 yo | Photophobia | HSV keratitis, treated with acyclovir eye ointment, followed by oral acyclovir | No improvement |
N/A – not available; N/S – not specified.