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. 2022 Dec 5;26(1):105726. doi: 10.1016/j.isci.2022.105726

Figure 4.

Figure 4

Cross-reactivity to betacoronaviruses of MBCs primed by SARS-CoV-2 infection and/or vaccination

(A) Cumulative MBC cross-reactivity between SARS-CoV-2 S and the four betacoronaviruses SARS-CoV, MERS-CoV, HCoV-HKU1, and HCoV-OC43. Shown are average OD values as measured by ELISA with blank subtracted from n = 2 replicates of 3744, 2880, and 2304 MBC cultures analyzed from 39 convalescent, 30 naive, and 24 infected donors after two vaccine doses. S2-specific MBCs are shown in red. Numbers of S- and S2-specific MBCs are indicated in the bottom-right quadrants of each panel. Cumulative fractions of S- and S2-cross-reactive (CR) MBCs are indicated as a percentage in the top-right quadrant.

(B) Individual fractions of SARS-CoV-2 S- (left) and S2-specific MBCs (right) that cross-react with the four betacoronaviruses in 39 convalescent, 30 naive and 24 infected vaccinated donors. Significant differences are indicated as ∗∗∗ (p-value < 0.001); ∗∗ (p < 0.002), ∗ (p < 0.033). See also Figure S4.