Table 1.
Comparison in clinical differences in individuals with mpox, according to HIV status
| Source |
Number of PLWH n/total (%) |
Median CD4 cell count (IQR), /μl |
PLWH with viral load > 200 copies/ml n/total (%) |
Differences between PLWH and HIV‐negative individuals with mpox |
|---|---|---|---|---|
| Tarín‐Vicente et al. [6] | 72/181 (40) | na (8/72 had a CD4 cell count <500) | na | No differences in clinical severity or disease progression |
| Thornhill et al. [7] | 218/528 (41) | 680 (513–861) | 5/190 (3) |
Similar clinical presentations No differences in the frequency of hospitalization |
| Hoffmann et al. [8] | 256/546 (47) | 691 (185–1603) a (7/244 had a CD4 cell count <350) | 4/236 (2) | No differences in clinical presentation or hospitalization rates |
| Angelo et al. [9] | 92/226 (41) | 713 (500–885) (1/92 had a CD4 cell count <200) | 7/83 (8) | PLWH more likely to present with diarrhoea and perianal rash with a higher lesion burden |
| Curran et al. [10] | 755/1969 (38) | 639 (452–831) (25/755, 3% had a CD4 cell count <200) | 137/755 (18) | PLWH were more likely to report rectal pain, tenesmus and proctitis |
| Ogoina et al. [12] | 9/40 (22) b | na (at least 7/9 had a CD4 cell count <350) | > 5/9 (>55) | PLWH were more likely to have skin rashes ≥2 cm, genital ulcers, secondary bacterial skin infection and longer duration of illness |
| Silva et al. [13] | 109/205 (53) | 527 (379–827) | 8/87 (9) | PLWH were older, had higher prevalence of HCV coinfection, anal lesions and clinical features of proctitis |
| Miller et al. [14] | 47/57 (82) b | na (40/43 had a CD4 cell count <200) | > 43/47 (>92) | Hospitalized PLWH with severe mpox were mostly not on cART and with low CD4 count. In 5/12 deaths reported, mpox was the cause of death or a contributing factor |
Abbreviations: IQR, interquartile range; PLWH, people living with HIV.
a
Range.
b
All patients were hospitalized.