Table 1.
Inhibitory potencya of 24 primary hits against pseudovirus infection identified in the US FDA-approved drug library screening and their pharmacological target molecules.
Compound | Target | rVSVΔG-GFP/SARS2-S |
rVSVΔG-GFP/VSVG |
||
---|---|---|---|---|---|
GFP (%) | Hoechst (%) | GFP (%) | Hoechst (%) | ||
Bazedoxifene acetate | NR3A (ESR) | 12.26 | 88.96 | 115.01 | 102.51 |
Toremifene | NR3A (ESR) IGF1R (CD221) |
21.77 | 101.27 | 142.24 | 90.44 |
Tamoxifen citrate | NR3A (ESR) | 16.27 | 99.67 | 105.72 | 97.14 |
Toremifene citrate | NR3A (ESR) IGF1R (CD221) |
8.32 | 99.98 | 109.35 | 98.74 |
Raloxifene hydrochloride | NR3A (ESR) | 9.66 | 101.70 | 97.55 | 103.53 |
Vandetanib (ZD6474) | VEGFR2 EGFR RET |
20.29 | 104.11 | 107.38 | 99.04 |
AZD-9291 mesylate | EGFR | 5.36 | 98.67 | 112.06 | 98.67 |
Prochlorperazine Maleate | DRD2 | 16.56 | 97.05 | 131.30 | 93.26 |
Thioridazine hydrochloride | DRD2 | 15.80 | 98.59 | 118.64 | 95.38 |
Fluphenazine hydrochloride | DRD2 | 19.31 | 103.35 | 106.20 | 100.59 |
Perphenazine | DRD2 | 17.90 | 104.54 | 113.49 | 86.64 |
Trifluoperazine dihydrochloride | DRD2 | 8.63 | 107.56 | 129.52 | 97.29 |
Chlorpromazine hydrochloride | HTR2 HRH1 ADRA2 DRD2 CHRM |
24.88 | 98.41 | 95.70 | 97.98 |
Asenapine Maleate | HTR1A HTR2A HTR2C HTR6 HTR7 DRD2 |
14.81 | 98.20 | 150.43 | 95.98 |
Sertraline hydrochloride | SLC6A4 (HTT) | 15.85 | 101.27 | 104.62 | 97.33 |
Trimipramine maleate | SLC6A2 (NAT1) SLC6A4 (HTT) |
23.16 | 103.55 | 90.44 | 99.90 |
Nortriptyline hydrochloride | SLC6A2 (NAT1) SLC6A4 (HTT) |
17.44 | 81.23 | 91.71 | 76.77 |
Amoxapine | SLC6A4 (HTT) SLC6A2 (NAT1) |
23.68 | 102.06 | 116.48 | 99.31 |
Paroxetine hydrochloride | SLC6A4 (HTT) | 21.00 | 102.73 | 112.39 | 98.03 |
Clemastine fumarate | HRH1 | 12.46 | 106.94 | 104.53 | 101.47 |
Dronedarone hydrochloride | CACNA1-L KCND3 KCNH2 KCNQ1 KCNJ3 KCNJ5 KCNJ11 ADRA1 ADRB1 |
10.87 | 99.72 | 138.68 | 101.34 |
Azithromycin dihydrate | 50 S ribosomal subunit | 18.36 | 100.22 | 101.10 | 101.30 |
Cinacalcet hydrochloride | CASR | 23.68 | 97.33 | 131.09 | 95.94 |
Imatinib Mesylate (STI571) | BCR-ABL FIP1L1-PDGFRA KIT (CD117) |
20.79 | 96.53 | 103.15 | 94.49 |
The mean value of vehicle-treated cells was set to 100%.