Table 1.
Effects of the anti-NGF Fab’-PEG or IgG on dams and embryo-fetal and postnatal development in rats.
| Drug | Anti-NGF IgG | Anti-NGF Fab’-PEG | |||||
|---|---|---|---|---|---|---|---|
| Dose (mg/kg) | 10 | 30 | 100 | 3 | 10 | 30 | |
| Day of dosing | GD7,14 | Every 2 days from GD7 to GD19 | |||||
| Number of dams | 5 | 6 | 6 | 6 | 6 | 6 | |
| F0 Dams | |||||||
| Died or sacrificed moribund | (-) | (-) | |||||
| General signs | (-) | (-) | |||||
| Body weight | Gestation period | (-) | (-) | ||||
| Lactation period | Decrease | (-) | |||||
| Food consumption | Gestation period | (-) | (-) | ||||
| Lactation period | Decrease | (-) | |||||
| Mean duration of gestation (days) | (-) | (-) | |||||
| Abnormal parturition | (-) | (-) | |||||
| Gestation index (%) | (-) | (-) | |||||
| F1 Pups | |||||||
| Total No. of pups delivered (mean) | 72 (14.4) | 81 (13.5) | 80 (13.3) | 90 (15.0) | 80 (13.3) | 82 (13.7) | |
| Total No. of live pups (mean) | 72 (14.4) | 80 (13.3) | 80 (13.3) | 88 (14.7) | 78 (13.0) | 82 (13.7) | |
| Live birth index (%) | (-) | (-) | |||||
| No. of pups with milk in stomach | Decrease | (-) | |||||
| Body weight | Decrease | (-) | |||||
| Viability index at LD 4 (%) § | 45.7 | 70.1 | 86.3 | 99.1 | 100 | 94.9 | |
| Weaning index (%) ¶ | 0 | 0 | 0 | 100 | 100 | 100 | |
| General signs | Found dead or cannibalized | Increase | (-) | ||||
| Trauma | Increase | (-) | |||||
| Pain response | 2/9 | 0/6 | 0/8 | 48/48 | 48/48 | 46/46 | |
§Viability index (%) = (No. of live pups before cull (LD 4)/No. of pups delivered) × 100
¶Weaning index (%) = (No. of live pups at LD 21/No. of live pups after cull (LD 4)) × 100
GD: gestational day, LD: lactation day