Table 1.

Main immunization approaches for RSV in infants and children.

mAbs	Maternal Vaccines	Pediatric Vaccines
Immunisation of infants at start of RSV season: Infants born in season immunized at birth Infants born before the season immunised at the start of the season Rapid and direct protection Duration at least 5 months (RSV season) with one injection	Vaccination of pregnant women in third trimester to protect neonates born in the RSV season through transplacental transfer of maternal antibodies Protection of neonate from birth Duration equivalent to the half-life of maternal antibodies (variable in the various studies between 21–27 days and 36–42 days) with actual efficacy waning after the first trimester of age.	Older infants and children vaccinated as part of a schedule, allowing time to develop an immune response Requires a mature immune system and time to mount an effective response Protection for one season and potentially beyond