Protein | Function |
---|---|
M | Matrix protein. Non-glycosylated phosphorylated protein located external to the nucleocapsid layer, where it acts as a bridge between the lipid bilayer envelope and the nucleocapsid. |
N | Nucleoprotein. Structural protein involved in the packaging of the viral RNA |
P | Phosphoprotein. Interacts with L protein in the RNA replication. |
L | RNA Polymerase. Replicates the viral RNA. |
NS1/NS2 | Non structural proteins. Involved in the evasion of the innate immune response |
M2-1/M2-2 | Regulatory proteins, involved in the regulation of the transcription and replication of the genome |
SH | Small hydrophobic protein. Involved in the immune evasion (?) |
G | Glycoprotein G, involved in: docking of the virion to the C×3C Chemochine Receptor 1 (CX3CR1) and glycosaminoglycans of the cell surface; inhibiting production of Interferon type I; promotion of Th-2 polarized response |
F | Glycoprotein F, fusion protein, eliciting the fusion between the virion and the targeted cell, with resulting infection of the cytoplasm. Target protein: surface nucleolin |