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. 2022 Jun 20;18(4):2079322. doi: 10.1080/21645515.2022.2079322
Protein Function
M Matrix protein. Non-glycosylated phosphorylated protein located external to the nucleocapsid layer, where it acts as a bridge between the lipid bilayer envelope and the nucleocapsid.
N Nucleoprotein. Structural protein involved in the packaging of the viral RNA
P Phosphoprotein. Interacts with L protein in the RNA replication.
L RNA Polymerase. Replicates the viral RNA.
NS1/NS2 Non structural proteins. Involved in the evasion of the innate immune response
M2-1/M2-2 Regulatory proteins, involved in the regulation of the transcription and replication of the genome
SH Small hydrophobic protein. Involved in the immune evasion (?)
G Glycoprotein G, involved in:
docking of the virion to the C×3C Chemochine Receptor 1 (CX3CR1) and glycosaminoglycans of the cell surface; inhibiting production of Interferon type I; promotion of Th-2 polarized response
F Glycoprotein F, fusion protein, eliciting the fusion between the virion and the targeted cell, with resulting infection of the cytoplasm. Target protein: surface nucleolin