Summary of findings 3. Exercise compared to bright light therapy for adults with depression.

Exercise compared to bright light therapy for adults with depression
Patient or population: adults with depression Settings: Intervention: Exercise Comparison: bright light therapy
Outcomes	Illustrative comparative risks* (95% CI)		No of Participants (studies)	Quality of the evidence (GRADE)	Comments
	Assumed risk	Corresponding risk
	Bright light therapy	Exercise
Symptoms of depression		The mean symptoms of depression in the intervention groups was 6.4 lower (10.2 to 2.6 lower)	18 (1 study)	⊕⊝⊝⊝ very low1,2,3	MD ‐6.40 (95% CI: ‐10.20 to ‐2.60). Although this trial suggests a benefit of exercise, it is too small to draw firm conclusions
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval;
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate.

1 Lack of blinding of outcome assessors probably increased effect sizes and drop‐out rates were not reported. Also sequence generation and concealment was considered unclear.
 2 The study included was relevant to the review question, particularly given that all studies had to meet the criteria of the ACSM definition of exercise.
 3 Based on 18 people