Blumenthal 2012a.

Methods	RCT
Participants	35 years or older with documented coronary artery disease and depressive symptoms (n=101)
Interventions	1. Exercise (group walking, running or jogging on treadmill (n = 37; 65% men) 2. Sertraline (n = 40; 63% men) 3. Placebo (n = 24; 83% men)
Outcomes	Depression as diagnosed by DSM‐IV and severity of depression as rated on HAM‐D; heart disease biomarkers
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐based randomisation
Allocation concealment (selection bias)	Low risk	Allocation through distribution of sealed envelopes
Blinding (performance bias and detection bias) participants	Unclear risk	Not possible to blind participants receiving exercise; unclear effect on bias
Blinding (performance bias and detection bias) those delivering intervention	Unclear risk	No detail given
Blinding (performance bias and detection bias) outcome assessors	Low risk	Telephone surveys (HAMD) by psychologists blinded to arm of trial
Incomplete outcome data (attrition bias) All outcomes	Low risk	95 out of 101 completed protocol and outcome assessment
Selective reporting (reporting bias)	Low risk	Prespecified outcomes reported in results. There is a study protocol
Other bias	Unclear risk	Unclear