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. 2013 Sep 12;2013(9):CD004366. doi: 10.1002/14651858.CD004366.pub6

Dunn 2005.

Methods RCT
Participants Community volunteers recruited via media. Men or women aged 20 to 45 with mild to moderate depression
 Mean age 35.9
 75% women
 N = 80
Interventions 4 different aerobic exercise programmes, that varied in total energy expenditure (7.0 kcal/kg/week or 17.5 kcal/kg/week) and frequency (3 days per week or 5 days per week). The 17.5 kcal/kg/week is consistent with public health recommendations for physical activity and is termed 'public health dose'.
 1. Public health dose 3/week (n = 17)
 2. Public health dose 5/week (n = 16)
 3. Low dose 3/week.(n = 16)
 4. Low dose 5/week (n = 18)
 5. Control, (flexibility exercise) 3 sessions per week (n = 13)
Exercise was on a treadmill or stationary bike, individually and monitored by laboratory staff.
 Duration 12 weeks.
Outcomes Change in HRSD from baseline to 12 weeks.
Notes Intention‐to‐treat (though data from the last available exercise session rather than data collected at 12 weeks were used in the analysis)
 Outcome assessors blind
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Method of sequence generation not stated
Allocation concealment (selection bias) Low risk Opaque sealed envelopes
Blinding (performance bias and detection bias) 
 participants Unclear risk Participants not blind to treatment allocation, but unclear effect on bias
Blinding (performance bias and detection bias) 
 those delivering intervention Unclear risk Those supervising delivery of the intervention were not blind, but it is unclear what effect this had on bias
Blinding (performance bias and detection bias) 
 outcome assessors Low risk Trained research assistants applied the HRSD blind to treatment allocation
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Intention‐to‐treat analyses
Selective reporting (reporting bias) Low risk There is a published protocol (Dunn 2002)
Other bias Unclear risk Unclear