Mota‐Pereira 2011.

Methods	RCT
Participants	18 ‐ 60 year‐olds with treatment resistant major depressive disorder selected from outpatient setting (n = 33)
Interventions	1. Five sessions a week of 30 ‐ 45 minutes moderate intensity walking. Four of these were unsupervised and one was supervised on a hospital gym treadmill (n = 22, 57.9% women) 2. Control group, receiving no exercise (n = 11 : 80% women)
Outcomes	Hamilton Depression Scale Global Assessment of Functioning Scale Clinical Global Impression Scale.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No details provided
Allocation concealment (selection bias)	Unclear risk	No details provided
Blinding (performance bias and detection bias) participants	Unclear risk	Participants were not blinded to intervention, but were not provided with information on how the intervention might benefit them.
Blinding (performance bias and detection bias) those delivering intervention	Unclear risk	Those delivering intervention not blinded to treatment group
Blinding (performance bias and detection bias) outcome assessors	Low risk	Investigators carrying out rating tests post‐intervention were blinded to treatment group
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing data
Selective reporting (reporting bias)	Low risk	Prespecified outcomes all reported
Other bias	Low risk	Appears to be free of other bias