Table 2.

Comparison of concentrations of C-reactive protein [CRP], faecal calprotectin [fCal], and faecal myeloperoxidase [fMPO] protein between individuals in endoscopic remission and those with active, mild, moderate, and severe disease activity.

Crohn’s disease
Biomarker concentration [geometric mean, 95% CI]	Remission [SES-CD ≤ 2]	Endoscopically active [SES-CD > 2]	Mild Activity [SES-CD 3–6]	Moderate Activity [SES–CD 7-15]	Severe Activity [SES-CD > 15]
CRP [mg/L]	2.1 [1.46–3.03]	4.26a [3.1–5.9]	3.0a [2.0–4.7]	5.10a [2.72–9.58]	10.2a [4.35–24.29]
fCal [µg/g]	54.60 [35.16–84.77]	244.69a [169.02–357.81]	109.95a [75.94–159.17]	601.85a [317.35–1141.39]	749.95a [249.64–2252.96]
fMPO [µg/g]	6.69 [4.22–10.49]	22.20a [14.01–35.16]	8.41 [5.47–13.07]	64.72a [29.67–139.77]	89.12a [21.33–376.15]

Ulcerative colitis
Biomarker concentration [geometric mean, 95% CI]	Remission [UCEIS ≤ 1]	Endoscopically active [UCEIS ≥ 2]	Mild activity [UCEIS 2–4]	Moderate activity [UCEIS 5–6]	Severe Activity [UCEIS ≥ 7]
CRP [mg/L]	1.80 [1.35–2.44]	6.96a [4.01–12.18]	1.80a [1.35–2.43]	9.87a [1.72–56.26]	33.11a [13.74–79.84]
fCal [µg/g]	56.83 [36.23–88.23]	645.48a [376.15–1096.63]	333.62a [175.91–632.70]	1685.81a [492.75–5825.50]	2344.90a [1053.63–5218.68]
fMPO [µg/g]	5.21 [3.03–8.93]	60.34a [33.12–103.95]	26.84a [13.33–54.05]	194.42a [59.74–632.70]	307.97a [144.03–651.97]

SES-CD, Simple Endoscopic Score for Crohn’s Disease; UCEIS, Ulcerative Colitis Endoscopic Index of Severity; CI, confidence interval.

Biomarker significantly different from endoscopic remission [p < 0;05].