Table 3.

Area under the receiver operating characteristic curve [AUROC] and optimal cut-off points for biomarkers (C-reactive protein [CRP], faecal calprotectin [fCal], and faecal myeloperoxidase [fMPO] protein) to maximise sensitivity and specificity in predicting for endoscopic disease activity and moderate-severe endoscopic activity in IBD.

Predicting endoscopic activity [SES-CD > 2, UCEIS > 1]
Crohn’s disease	AUROC	Optimal cut-off points	Sensitivity/specificity [%]
CRP	0.66a	3.5 mg/L	53/74
fCal	0.77a	58.24 µg/g	87/60
fMPO	0.69a	10.25 µg/g	63/69

Ulcerative colitis	AUROC	Optimal cut-off points	Sensitivity/specificity [%]
CRP	0.73a	3.5 mg/L	63/78
fCal	0.89a	137.50 µg/g	89/78
fMPO	0.85a	4.64	94/62

IBD combined		Optimal cut-off points	Sensitivity/specificity [%]
CRP	0.69a	3.5 mg/L	56/76
fCal	0.81a	147.61 µg/g	65/82
fMPO	0.76a	7.39 µg/g	75/67

Predicting moderate-severe endoscopic activity [SES-CD > 6, UCEIS > 4]
Crohn’s disease	AUROC	Optimal cut-off points	Sensitivity/specificity [%]
CRP	0.70a	3.5 mg/L	68/67
fCal	0.87a	252.14 µg/g	79/84
fMPO	0.86a	23.07 µg/g	82/81

Ulcerative colitis	AUROC	Optimal cut-off points	Sensitivity/specificity [%]
CRP	0.81a	10.5 mg/L	62/93
fCal	0.94a	270.00 µg/g	100/76
fMPO	0.92a	75.60 µg/g	92/88

IBD combined	AUROC	Optimal cut-off points	Sensitivity/specificity [%]
CRP	0.74a	3.5 mg/L	73/67
fCal	0.88a	252.14 µg/g	83/79
fMPO	0.87a	58.83 µg/g	76/90

SES-CD ,  Simple Endoscopic Score for Crohn’s Disease; UCEIS ,  Ulcerative Colitis Endoscopic Index of Severity; IBD ,  inflammatory bowel disease.

Area under the receiver operating characteristic curve [AUROC] statistically significant [p < 0.05].