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. Author manuscript; available in PMC: 2022 Dec 5.
Published in final edited form as: J Ultrasound Med. 2018 Aug 16;38(3):811–819. doi: 10.1002/jum.14765

Table 1.

Demographics, Baseline Characteristics, and Follow up of Patients Who Underwent Contrast-Enhanced TRUS Imaging After Prostate Hemigland HIFU Ablation

Characteristic Case 1 Case 2 Case 3 Case 4 Case 5 Case 6 Case 7

Age, y 46 72 63 61 41 66 80
PSA, ng/mL 5.2 4.0 4.2 6.5 9.1 3.1 11.0
Clinical stage (DRE)  cT1c  cT2a  cT2a  cT1c  cT1c  cT1c cT2b
Previous treatment for prostate cancer  No  No  No  No  No  No Cryo, sEBRT
Pre-HIFU multiparametric MRI
 PI-RADS score
3  NAa 5 No lesion 5  NAb  No lesion
 Size of lesion, mm 9 18 18 12
Pre-HIFU TRUS and biopsy
Prostate volume, cm3
27 26 26 46 36 23 18
 No. of positive cores 6 6 2 1 2 2 5
 Gleason grade group 2 3c 3c 4c 2 1 5c
 Maximum cancer core, % 40 80 60 5 50 10 50
 Follow-up time, mo 20 20 16 15 14 13 13
 Time to PSA nadir, mo 3 6 12 3 2 3 3
 PSA nadir, ng/mL 0.83 0.2 0.77 3.4 2.3 2.2 0.68
 Reduction in PSA at nadir, % 84 95 82 48 75 30 94
Follow up contrast-enhanced TRUS
TRUS prostate volume, cm3
15 13 17 12 18 16 18
 Reduction in prostate volume, % 44 50 35 74 50 30 0
 Ablation zone visualized Yes Yes Yes Yes Yes Yes Yes
Time-intensity curve enhancement patterns
 Enhancement in the treated lobe
E1 E0 E0 E1 E0 E2 E0
 Discrete lesion in the treated lobe E0 E0 E0 E0 E2 E0 E2
 Enhancement in the untreated lobe E2 E2 E1 E2 E1 E2 E1
Follow-up multiparametric MRI
 PI-RADS score
No lesion NAa No lesion No lesion 4 NAb 4
Follow-up prostate biopsy
 Follow-up biopsy performed Yes Yes Yes Yes Yes Yes Yes
 Positive biopsy results in treated lobe No No No No Yes Yes Yes
 Gleason grade group 2 1 4
 Maximum cancer core, % 50 20 30

Cryo indicates cryoablation; DRE, digital rectal examination; E0, no enhancement; E1, mild or patchy enhancement; E2, marked enhancement; NA, not applicable; PI-RADS, Prostate Imaging Reporting and Data System; and sEBRT, salvage external beam radiation therapy.

a

Patient could not have MRI because of the presence of a defibrillator.

b

Patient could not have MRI because of claustrophobia.

c

These 4 patients with high-risk or recurrent prostate cancer specifically requested HIFU hemiablation; additional imaging was performed to rule out metastases.