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Glypicans: signaling and congenital diseases
| Glypican | Signaling Pathway Altered in Knockout Mice | Human Congenital Syndrome |
|---|---|---|
| GPC1 | FGF | |
| GPC2 | ND | |
| GPC3 | Hh, Wnt, BMP | Simpson–Golabi–Behmel |
| GPC4 | ND | Keipert |
| GPC5 | ND | |
| GPC6 | Hh, Wnt | Recessive omodysplasia |
BMP, bone morphogenetic protein; FGF, fibroblast growth factor; Hh, hedgehog; ND, not determined.
