Table 2.
Evaluation parameters of the prepared fast-dissolving films of levocetirizine dihydrochloride (LF1-1-LF-7).
| Evaluation parameter | Formulation code | ||||||
|---|---|---|---|---|---|---|---|
| LF-1 | LF-2 | LF-3 | LF-4 | LF-5 | LF-6 | LF7 | |
| Appearance | Transparent | Transparent | Transparent | Transparent | Opaque | Opaque | Opaque |
| Weight variation (mg) | 21.77 | 23.81 | 24.21 | 25.91 | 28.43 | 29.02 | 30.29 |
| ±1.81 | ±2.20 | ±2.80 | ±2.60 | ±2.51 | ±3.01 | ±2.01 | |
| Thickness (μm) | 20.78 | 23.22 | 23.89 | 23.56 | 24.44 | 25.63 | 27.46 |
| ±1.80 | ±1.73 | ±1.96 | ±2.28 | ±1.58 | ±1.69 | ±1.09 | |
| Folding endurance | >300 | >300 | >300 | >300 | >300 | >300 | >300 |
| Surface pH | 5.80 | 5.96 | 5.69 | 5.84 | 5.94 | 5.91 | 5.85 |
| ±0.11 | ±0.12 | ±0.18 | ±0.20 | ±0.10 | ±0.15 | ±0.15 | |
| Drug content uniformity (%) | 99.72 | 97.67 | 102.68 ± 1.31 | 96.06 | 99.73 | 98.21 | 98.31 |
| ±2.70 | ±1.23 | ±1.40 | ±1.20 | ±0.8 | ±1.02 | ||
| Moisture uptake (%) | 5.71 | 6.76 | 5.33 | 5.11 | 6.20 | 6.62 | 6.88 |
| ±0.06 | ±0.16 | ±0.15 | ±0.13 | ±0.09 | ±0.10 | ±0.10 | |
| Moisture loss (%) | 5.88 | 6.54 | 6.90 | 4.17 | 5.77 | 5.38 | 5.20 |
| ±0.071 | ±0.12 | ±0.14 | ±0.07 | ±0.11 | ±0.13 | ±0.12 | |
| In vitro disintegration (Sec.) | 54 | 47 | 40 | 30 | 35 | 28 | 25 |
| ±2.00 | ±1.50 | ±2.50 | ±3.00 | ±1.5 | ±2.5 | ±2.00 | |
| In vitro drug released (%) after one min. | 50.29 | 46.49 | 55.71 | 86.82 | 80.4 | 83.52 | 99.22 |
| ±2.97 | ±3.47 | ±3.05 | ±2.20 | ±3.30 | ±3.40 | ±2.20 | |
(n = 3; mean ± SD).