Table 4.
Comparing hematological parameters before and after administration of ferric carboxymaltose by the severity of anemia
| Severity of anemia | Parameters | N | At baseline (mean ± SD) | At 4 weeks (mean ± SD) | Mean improvement ± SD |
|---|---|---|---|---|---|
| Severe | Hemoglobin (g/dL) | 103 | 6.49 ± 0.41 | 10.09 ± 1.11 | 3.6 ± 1.08∗ |
| Ferritin (μg/L) | 46 | 51.88 ± 58.3 | 68.84 ± 39.47 | 16.96 ± 72.52NS | |
| RBC (mn/mm3) | 38 | 3.53 ± 0.59 | 4.56 ± 0.89 | 1.03 ± 1.22∗ | |
| Hematocrit (%) | 37 | 32.82 ± 7.74 | 32.22 ± 14.28 | 0.6 ± 10.7NS | |
| MCV (fL) | 46 | 75.82 ± 11.35 | 68.61 ± 25.62 | 7.2 ± 27.87NS | |
| MCH (pg) | 45 | 25.75 ± 6.15 | 28.03 ± 5.59 | 2.28 ± 6.16# | |
| MCHC (g/dL) | 44 | 28.65 ± 3.52 | 29.67 ± 10.52 | 1.03 ± 9.34NS | |
|
| |||||
| Moderate | Hemoglobin (g/dL) | 978 | 8.14 ± 0.72 | 10.87 ± 1.03 | 2.74 ± 0.98∗ |
| Ferritin (μg/L) | 203 | 36.13 ± 43.7 | 69.12 ± 73.88 | 33 ± 48.54∗ | |
| RBC (mn/mm3) | 174 | 4.21 ± 0.67 | 4.68 ± 0.92 | 0.47 ± 1.04∗ | |
| Hematocrit (%) | 165 | 33.43 ± 5.09 | 35.89 ± 5.92 | 2.46 ± 4.79∗ | |
| MCV (fL) | 202 | 68.07 ± 9.35 | 77.64 ± 14.96 | 9.58 ± 17.49∗ | |
| MCH (pg) | 200 | 24.04 ± 6.38 | 27.73 ± 6.23 | 3.68 ± 7.6∗ | |
| MCHC (g/dL) | 198 | 29.75 ± 2.83 | 31.22 ± 16.01 | 1.48 ± 15.39NS | |
|
| |||||
| Mild | Hemoglobin (g/dL) | 26 | 10.18 ± 0.25 | 12.17 ± 0.77 | 1.99 ± 0.8∗ |
| Ferritin (μg/L) | 2 | 8 ± 9.9 | 37.1 ± 32.39 | 29.1 ± 22.49NS | |
| RBC (mn/mm3) | 2 | 3.93 ± 0.1 | 4.13 ± 0.18 | 0.2 ± 0.28NS | |
| Hematocrit (%) | 2 | 32.25 ± 1.34 | 34.25 ± 2.33 | 2 ± 0.99NS | |
| MCV (fL) | 1 | 61.4 ± 0 | 80.6 ± 0 | — | |
| MCH (pg) | 2 | 26.15 ± 8.27 | 33.4 ± 9.33 | 7.25 ± 1.06NS | |
| MCHC (g/dL) | 2 | 31.6 ± 2.55 | 31.65 ± 2.33 | 0.05 ± 4.88NS | |
∗ P value <0.001, statistically significant difference; NS-P value >0.05, nonsignificant difference. %-percentage; μg/L-micrograms per liter; fL-femtoliters; g/dL-grams per deciliter; MCH-mean corpuscular hemoglobin; MCHC-mean corpuscular hemoglobin concentration; MCV-mean corpuscular volume; mn/mm3-million per millimeter cube; N-number of participants; pg-pictograms; RBC-red blood cell; SD-standard deviation. Note: 4 weeks is 4 ± 1 week.