Table 2.
Correlation between NPTM and major clinic-pathological traits.
| Patient characteristics | NPTM | P value∗ | ||||
|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | ||
| Gender | ||||||
| Female | 150 (32.7) | 65 (26.6) | 30 (25.4) | 18 (26.5) | 13 (33.3) | 0.324 |
| Male | 309 (67.3) | 179 (73.4) | 88 (74.6) | 50 (73.5) | 26 (66.7) | |
| Age at diagnosis | ||||||
| ≤60 | 262 (57.1) | 130 (53.3) | 53 (44.9) | 27 (39.7) | 14 (35.9) | 0.004 |
| >60 | 197 (42.9) | 114 (46.7) | 65 (55.1) | 41 (60.3) | 25 (64.1) | |
| Body mass index | ||||||
| <24 | 260 (56.6) | 146 (59.8) | 71 (60.2) | 43 (63.2) | 26 (66.7) | 0.622 |
| ≥ 24 | 199 (43.4) | 98 (40.2) | 47 (39.8) | 25 (36.8) | 13 (33.3) | |
| Family history | ||||||
| No | 397 (86.5) | 202 (82.8) | 103 (87.3) | 62 (91.2) | 35 (89.7) | 0.363 |
| Yes | 62 (13.5) | 42 (17.2) | 15 (12.7) | 6 (8.8) | 4 (10.3) | |
| Hypertension | ||||||
| No | 375 (81.7) | 201 (82.4) | 96 (81.4) | 47 (69.1) | 31 (79.5) | 0.154 |
| Yes | 84 (18.3) | 43 (17.6) | 22 (18.6) | 21 (30.9) | 8 (20.5) | |
| Diabetes | ||||||
| No | 425 (92.6) | 222 (91.0) | 101 (85.6) | 64 (94.1) | 34 (87.2) | 0.125 |
| Yes | 34 (7.4) | 22 (9.0) | 17 (14.4) | 4 (5.9) | 5 (12.8) | |
| Differentiation grade | ||||||
| Well | 81 (17.6) | 58 (23.8) | 31 (26.3) | 20 (29.4) | 14 (35.9) | 0.014 |
| Moderate | 97 (21.1) | 42 (17.2) | 24 (20.3) | 16 (23.5) | 2 (5.1) | |
| Poorly | 281 (61.2) | 144 (59.0) | 63 (53.4) | 32 (47.1) | 23 (59.0) | |
| Tumor location | ||||||
| Upper | 75 (16.3) | 53 (21.7) | 27 (22.9) | 18 (26.5) | 10 (25.6) | 0.395 |
| Middle | 118 (25.7) | 56 (23.0) | 28 (23.7) | 17 (25.0) | 7 (17.9) | |
| Lower | 266 (58.0) | 135 (55.3) | 63 (53.4) | 33 (48.5) | 22 (56.4) | |
| Tumor size (cm) | ||||||
| <5 | 256 (55.8) | 115 (47.1) | 48 (40.7) | 21 (30.9) | 12 (30.8) | <0.001 |
| ≥ 5 | 203 (44.2) | 129 (52.9) | 70 (59.3) | 47 (69.1) | 27 (69.2) | |
| pTNM | ||||||
| I | 74 (16.1) | 19 (7.8) | 5 (4.2) | 1 (1.5) | 0 (0.0) | <0.001 |
| II | 175 (38.1) | 79 (32.4) | 33 (28.0) | 16 (23.5) | 9 (23.1) | |
| III | 210 (45.8) | 146 (59.8) | 80 (67.8) | 51 (75.0) | 30 (76.9) | |
| Postoperative chemotherapy | ||||||
| No | 132 (28.8) | 61 (25.0) | 37 (31.4) | 21 (30.9) | 15 (38.5) | 0.404 |
| Yes | 327 (71.2) | 183 (75.0) | 81 (68.6) | 47 (69.1) | 24 (61.5) | |
Abbreviations: NPTM: number of positive tumor markers; BMI: body mass index; TNM: tumor-node-metastasis staging. ∗Difference between groups was tested by Chi-square test. Statistically significant values are in bold.