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. 2022 Nov 22;35:10772. doi: 10.3389/ti.2022.10772

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Copyright © 2022 Večerić-Haler, Sever, Kojc, Halloran, Boštjančič, Mlinšek, Oblak, Poženel, Švajger, Hartman, Kneževič, Barlič, Girandon, Aleš Rigler, Zver, Buturović Ponikvar and Arnol.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kidney graft function, peripheral blood lymphocyte populations and serum concentration of cytokines before and after application of MSCs in patient #1 and patient #2. Legend: eGFR, estimated glomerular filtration rate; conc, concentration; Treg, CD4⁺CD25⁺⁺ T cells (this subset contains a proportion of Tregs cells). Cytokine concentrations after mesenchymal stem cells application (in U/ml for soluble interleukin 2 receptor and in pg/ml for other cytokines); TNF, tumor necrosis factor; IL, interleukin; s-IL-2-R, soluble interleukin 2 receptor; IFN, interferon, *patient#2 received only two doses of MSCs.