Figure 1.

Change in Biomarkers from Baseline to last HIV negative Visit in Cases and Controls

Six of 10 analyzed biomarkers are shown, as measured in cryopreserved plasma by Meso Scale Discovery multiplex chemiluminescence assay, with striking differences in the relation of case versus control distributions at study entry versus last HIV negative visit (1 month before first positive HIV RNA or Ab result or matched visit for controls). For IL-2, TNF-α, IL-12p70, IL-10 the levels of these biomarkers were significantly lower in cases than controls at study entry, but the distributions were indistinguishable between groups at the last HIV negative visit. IL-6, IFNγ, and MIP-1α were also lower in cases than controls at baseline but had a trend toward remaining lower in cases at last negative visit (not shown, p < 0.10). IP-10 was higher in cases than controls at study entry but also indistinguishable at last HIV negative visit. IL-7 had similar distributions between cases and controls at entry, but controls had higher levels of IL-7 at last HIV negative visit. TNF-β was also higher in controls than cases at last HIV-negative timepoint but was not measured in baseline samples. All data in Table 2.