Table 1.
Clinical and demographic characteristics of the randomized (intent-to-treat) sample
Full intent-to-treat sample (n=154) | Ketamine+active ASAT sample (n=53) | Ketamine+sham ASAT sample (n=50) | Saline+active ASAT sample (n=51) | |||||
---|---|---|---|---|---|---|---|---|
| ||||||||
Race/ethnicity | ||||||||
Non-Hispanic Caucasian, n (%) | 116 | (75.32%) | 39 | (73.58%) | 37 | (74.00%) | 40 | (78.43%) |
Hispanic/Latino, n (%) | 11 | (7.14%) | 5 | (9.43%) | 2 | (4.00%) | 4 | (7.84%) |
African American, n (%) | 7 | (4.55%) | 3 | (5.66%) | 2 | (4.00%) | 2 | (3.92%) |
Asian, n (%) | 9 | (5.84%) | 4 | (7.55%) | 2 | (4.00%) | 3 | (5.88%) |
More than one race, n (%) | 11 | (7.14%) | 2 | (3.77%) | 5 | (10.00%) | 4 | (7.84%) |
Unknown/incomplete info, n (%) | 3 | (1.95%) | 0 | (0.00%) | 2 | (4.00%) | 1 | (1.96%) |
Sex | ||||||||
Assigned female sex at birth, n (%) | 97 | (63.0%) | 32 | (60.4%) | 32 | (64.0%) | 33 | (64.7%) |
Gender | ||||||||
Cisgender male, n (%) | 55 | (35.71%) | 21 | (39.62%) | 17 | (34.00%) | 17 | (33.33%) |
Cisgender female, n (%) | 90 | (58.44%) | 29 | (54.72%) | 28 | (56.00%) | 33 | (64.71%) |
Transgender: female-to-male, n (%) | 1 | (0.65%) | 1 | (1.89%) | 0 | (0.00%) | 0 | (0.00%) |
Transgender: male-to-female, n (%) | 1 | (0.65%) | 0 | (0.00%) | 0 | (0.00%) | 1 | (1.96%) |
Non-binary or gender fluid, n (%) | 2 | (1.30%) | 1 | (1.89%) | 1 | (2.00%) | 0 | (0.00%) |
Gender undisclosed/unknown, n (%) | 5 | (3.25%) | 1 | (1.89%) | 4 | (8.00%) | 0 | (0.00%) |
Age, mean (SD) | 34.26 | (10.5) | 34.7 | (10.1) | 34.6 | (11.6) | 33.5 | (9.9) |
# of failed adequate ADM trials, mean (SD) | 2.64 | (1.93) | 2.66 | (1.59) | 2.60 | (1.67) | 2.67 | (2.46) |
Taking psychotropic medication, n (%) | 122 | (79.2%) | 40 | (75.5%) | 42 | (84.0%) | 40 | (78.4%) |
Comorbid anxiety disorder, n (%) | 94 | (61.0%) | 30 | (56.6%) | 30 | (60.0%) | 34 | (66.7%) |
MADRS total score (pre-infusion baseline) | 32.78 | (5.3) | 32.28 | (5.7) | 33.48 | (4.9) | 32.61 | (5.1) |
Note: No variables in the table above differed as a function of treatment group according to unpaired t-tests (for continuous variables) or Chi-squared tests (for categorical variables) (p’s>.49). ASAT=Automated Self-Association Training; ADM=antidepressant medication