Table 1.
Baseline characteristics of entire cohort based on ductopenia score on index biopsy
| Score=0 n=21 |
Score=1 n=22 |
Score=2 n=20 |
Score=3 n=18 |
P | |
|---|---|---|---|---|---|
| Age (years) | 51 (35-67) | 52 (34-68) | 51 (32-67) | 49 (35-66) | 0.83 |
| White blood cell count (x 109/L) | 7.9 (3.2-13.8) | 7.2 (2.4-10.0) | 6.0 (3.1-10.9) | 6.6 (2.5-10.2) | 0.07 |
| Absolute neutrophil count (x 109/L) | 4.3 (1.3-8.3) | 4.2 (1.2-5.7) | 3.3 (1.6-6.4) | 3.7 (1.5-6.4) | 0.10 |
| Absolute lymphocyte count (x 109/L) | 2.5 (1.2-6.1) | 2.1 (0.7-3.9) | 2.0 (0.8-3.5) | 2.2 (0.7-4.0) | 0.43* |
| Hemoglobin (g/dL) | 13.8 (11.8-16.0) | 13.6 (11.9-16.1) | 13.1 (10.5-15.0) | 12.8 (10.9-14.5) | 0.05 |
| Platelet count (x 109/L) | 276 (85-403) | 282 (126-439) | 236 (94-357) | 274 (108-432) | 0.35 |
| Prothrombin time (sec.) | 11.9 (10.8-14.4) | 11.7 (10.6-13.7) | 11.5 (10.0-12.8) | 11.6 (10.4-12.8) | 0.57 |
| Total bilirubin (mg/dL) | 0.8 (0.3-2.6) | 0.8 (0.3-2.9) | 1.1 (0.5-5.0) | 2.0 (0.4-7.1) | 0.01 * |
| Direct bilirubin (mg/dL) | 0.3 (0-1.9) | 0.3 (0-2.9) | 0.5 (0-3.1) | 1.3 (0-5) | 0.002 * |
| ALT (U/L) | 99 (23-298) | 77 (26-137) | 100 (28-192) | 152 (77-314) | 0.002 # |
| AST (U/L) | 72 (20-259 | 60 (15-112) | 79 (26-149) | 121 (53-246) | 0.001 # |
| ALP (U/L) | 284 (78-1010 | 399 (68-1350) | 544 (113-1290) | 995 (256-2620) | 0.001 # |
| GGT (U/L) | 416 (26-1110) | 473 (36-1140) | 543 (49-1488) | 1083 (425-2095) | 0.001 |
| Albumin (mg/dL) | 4.1 (3.6-4.5) | 4.0 (2.9-4.8) | 3.9 (3.3-4.6) | 3.9 (3.3-4.7) | 0.63 |
| Creatinine (mg/dL) | 0.9 (0.7-1.2) | 1.0 (0.7-1.3) | 0.9 (0.6-1.3) | 0.9 (0.7-1.1) | 0.49 |
| IgM (mg/dL) | 460 (144-1200) | 480 (140-928) | 535 (144-1520) | 518 (95-1410) | 0.92* |
| APRI | 0.73 (0.15-2.15) | 0.62 (0.14-1.51) | 0.98 (0.22-2.60) | 1.25 (0.42-2.73) | 0.008 * |
| Mayo risk score | 3.97 (2.49-5.31) | 4.09 (2.71-6.35) | 4.21 (2.70-6.36) | 4.55 (3.38-6.11) | 0.23 |
| Ishak fibrosis | 1.57 (0-4) | 2.05 (0-4) | 2.30 (0-6) | 3.17 (1-6) | 0.009 * |
| Mean Ductular reaction | 0.48 (0-0.88) | 0.74 (0.43-1.33) | 0.64 (0.15-1.1) | 0.79 (0.38-1.33) | 0.28 |
| HAI Periportal inflammation | 2.7 (1-5) | 3.3 (1-6) | 3 (1-6) | 2.8 (1-6) | 0.55* |
| HAI Portal inflammation | 1.7 (1-4) | 1.5 (0-3) | 2.1 (0-3) | 1.7 (1-3) | 0.46* |
| Copper | 0.82 (0-3) | 0.60 (0-2) | 1.62 (1-3) | 1.46 (0-3) | 0.01 * |
| CK7 staining periportal | 1.20 (0-3) | 1.67 (1-3) | 1.67 (1-3) | 2.00 (1-3) | 0.16* |
| CK7 staining zone 3 | 0.80 (0-2) | 0.83 (0-1) | 1.22 (0-2) | 1.22 (0-2) | 0.36* |
All values are presented as mean and range and p values are obtained by ANOVA unless specified otherwise
*
Kruskal-Wallis test
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