Table 1.
Clinical characteristics by CRP-ferritin multi- trajectory group1
| CRP-ferritin Multi- Trajectory Group | ||||||
|---|---|---|---|---|---|---|
|
|
||||||
| Group 1 (N = 8) | Group 2 (N = 80) | Group 3 (N = 16) | Group 4 (N = 121) | Group 5 (N = 30) | P-value | |
| Age at onset of organ failure (in years) | 1 [0, 2] | 3 [1, 8] | 4 [0, 11] | 8 [3, 14] | 10 [6, 13] | <.0012 |
|
| ||||||
| Male | 3 (38%) | 42 (53%) | 9 (56%) | 75 (62%) | 14 (47%) | 0.3533 |
|
| ||||||
| PRISM | 6 [0, 12] | 7 [3, 12] | 15 [8, 22] | 9 [5, 15] | 9 [5, 13] | 0.0192 |
|
| ||||||
| OFI on Day 0 | 1 [1, 2] | 2 [1, 2] | 3 [1, 3] | 2 [1, 2] | 2 [1, 3] | 0.0992 |
|
| ||||||
| Cancer | 0 (0%) | 2 (3%) | 3 (19%) | 6 (5%) | 15 (50%) | <.0013 |
|
| ||||||
| Transplant | 0 (0%) | 2 (3%) | 2 (13%) | 5 (4%) | 11 (37%) | <.0013 |
|
| ||||||
| Chronic illness | 4 (50%) | 41 (51%) | 11 (69%) | 64 (53%) | 23 (77%) | 0.1043 |
|
| ||||||
| INFECTIONS AT ELIGIBILITY4 | ||||||
|
| ||||||
| Bacterial | 3 (38%) | 22 (28%) | 4 (25%) | 55 (45%) | 13 (43%) | 0.2753 |
|
| ||||||
| Viral | 4 (50%) | 35 (44%) | 4 (25%) | 25 (21%) | 8 (27%) | 0.0883 |
|
| ||||||
| Fungal | 0 (0%) | 0 (0%) | 0 (0%) | 2 (2%) | 1 (3%) | 0.6273 |
1
Only subjects with the first two samples were included in biomarker trajectory analyses.
2
Kruskal-Wallis test.
3
Fisher’s exact test (Monte Carlo approximation).
4
Documented infections at the time of study eligibility are reported. The statistical tests compare documented vs. suspected infections.