Table 2.
Outcomes by CRP-ferritin multi- trajectory group1
| CRP-ferritin multi-trajectory groups | ||||||
|---|---|---|---|---|---|---|
|
|
||||||
| Group 1 (N = 8) | Group 2 (N = 80) | Group 3 (N = 16) | Group 4 (N = 121) | Group 5 (N = 30) | P-value | |
| PICU mortality | <.0013 | |||||
|
| ||||||
| Survived | 8 (100%) | 76 (95%) | 15 (94%) | 108 (89%) | 18 (60%) | |
|
| ||||||
| Died | 0 (0%) | 4 (5%) | 1 (6%) | 13 (11%) | 12 (40%) | |
|
| ||||||
| Hospital Length of Stay (days) | 17 [13, 46] | 19 [13, 33] | 24 [13, 38] | 22 [15, 35] | 39 [20, 74] | 0.1082 |
|
| ||||||
| ICU Length of Stay (days) | 14 [11, 19] | 13 [9, 22] | 9 [6, 19] | 16 [10, 25] | 18 [11, 35] | 0.0782 |
|
| ||||||
| MAS | 0 (0%) | 1 (1%) | 4 (25%) | 8 (7%) | 6 (20%) | <.0013 |
|
| ||||||
| IPMOF | 2 (25%) | 13 (16%) | 4 (25%) | 33 (27%) | 20 (67%) | <.0013 |
|
| ||||||
| Maximum OFI | 2 [1, 2] | 2 [1, 2] | 3 [2, 3] | 2 [2, 3] | 3 [2, 4] | <.0012 |
|
| ||||||
| ECMO on study | 0 (0%) | 3 (4%) | 1 (6%) | 14 (12%) | 6 (20%) | 0.0803 |
|
| ||||||
| CRRT on study | 1 (13%) | 4 (5%) | 3 (19%) | 13 (11%) | 17 (57%) | <.0013 |
|
| ||||||
| Plasma exchange on study | 0 (0%) | 3 (4%) | 3 (19%) | 6 (5%) | 6 (20%) | 0.0143 |
|
| ||||||
| Mechanical ventilation (days) | 11 [9, 14] | 10 [8, 16] | 8 [3, 10] | 13 [7, 21] | 13 [8, 29] | 0.0592 |
1
Only subjects with the first two samples were included in biomarker trajectory analyses.
2
Kruskal-Wallis test.
3
Fisher’s exact test (Monte Carlo approximation).